Here is an overview of some considerations when first sitting down to design a web site. I would tend to agree, however I would out Audience at number 1.
1) Layout
A great example: YouLove.us
2) Navigation
A great example: Alex Buga
3) Usability
A great example: Tutorial 9
4) Audience
A great example: Bell Hospital
5) Colors
A great example: Icon Dock
6) Browser Compatibility
A great example: My Ink Blog
6 things to think about when building a website
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